Abstract

In the rat, the production of extensive and usually fatal myocardial necroses by fluorocortisol or desoxycorticosterone in combination with Na₂HPO₄ is greatly accelerated and aggravated by the oral administration of corn oil. Cortisol, progesterone and methyltestosterone do not produce myocardial necroses under these conditions even if, in addition to Na₂HPO₄, corn oil is given.

Not all sodium salts are equally potent in producing myocardial necroses when administered in combination with fluorocortisol and fat supplements. In this respect, NaH₂PO₄, Na₂HPO₄, NaClO₄ and NaHSO₄ are most effective, NaHCO₃ is somewhat less active, whereas NaCl is inactive under otherwise comparable conditions.

10.1016/0002-9149(69)90035-6

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